Endocrine Abstracts

Introduction: The silent corticotropinomas (SC) account for 1.1–6% of surgically removed pituitary adenomas and 17–22% of ACTH-immunoreactive tumours. They do not cause prominent clinical features of hypercortisolism, nor biochemically evident, but show positive immunostaining for ACTH similar to functional corticotropinomas, They usually present as non-functioning adenomas (NFPA) with local mass effects and/or visual impairment.Aim: To describ...

Introduction: Copeptin is a proposed new diagnostic marker in differential diagnosis of diabetes insipidus as it is secreted in equimolar concentrations with vasopressin. Thus our aim was to assess diagnostic value of copeptin evaluation in patients with polydipsic-polyuric disorders.Materials and Methods: We’ve evaluated the copeptin (BRAHMS CT-proAVP Kryptor), sodium levels and blood/urine osmolality in 26 healthy volunteers (1M/25F, mean age 24.7...

Introduction: Extremely low levels of vitamin D usually include levels < 4 ng/ml, which is almost the same as undetectable. The risk groups for vitamin D deficiency have been identified, but do they allow such patients to be identified based solely on clinical presentation.Objective: To identify risk factors and their actual clinical determination in patients with 25(OH)D serum levels <4 ng/ml.Materials and methods: The stu...

Prolactinomas are the most common hormone-active pituitary tumors, most common in young women, whose main reason for going to the doctor is menstrual irregularity. At the onset of the disease before puberty in children, there is a delay in sexual development, in girls primary amenorrhea.A 27-year old woman has been observed since 15 years, when hyperprolactinemia was first detected, level of PRL was 10 900 IU/l, and according to MRI pituitary endose...

Experience in complex therapy of selective and non-selective dopamine agonists in women with resistant prolactinomas for recovering of ovulation function.Introduction: Prolactinomas are the most common pituitary adenomas and dopamine agonists (DA) still remain the first choice of treatment. Nevertheless, it does not always exert an adequate effect and endocrinologists face the challenge of resistant prolactinomas more frequently. This problem is very imp...

Silent corticotropinomas (SCAs) are a subtype of non-functioning pituitary adenomas (NFPAs) demonstrating positive immunoreactivity for ACTH, but without clinical or biochemical features of hypercortisolism. SCAs typically present as macroadenomas with symptoms related to a local mass effect. In some cases SCAs can transform into hormonal active formations with gradually developing symptoms of hypercortisolism.The aim: To describe a patient with NFPA who...

Introduction: Hyponatriemia is one of severe postoperative water-electrolyte disturbances. This condition is usually caused by syndrome of inappropriate secretion of antidiuretic hormone or cerebral salt-wasting syndrome which require different treatment approaches.Case presentation: A 61-year-old woman was referred to tertiary care center with non-functioning pituitary macroadenoma. The patient had been suffering from headaches for 4 later years and had...

Central diabetes insipidus (CDI) is a common complication after transsphenoidal treatment for tumors of the sellar region and may exhibit different patterns: transient, permanent or triphasic.The aim of our study was to determine the incidence and course of the CDI and to characterize the factors associated with resolution of this disease.The incidence of CDI was based on records of 318 patients who underwent transsphenoidal surger...

Aim: To assess the diagnostic value of a 3% hypertonic saline infusion test in comparison with a set of clinical and laboratory data (including a water deprivation test and MRI data) for the purpose of differential diagnosis between ADH deficiency and primary polydipsia (PP).Materials and Methods: An interventional comparative study included 90 patients with confirmed polyuria-polydipsia syndrome. In order to assess the diagnostic characteristics, all su...

Introduction: Vitamin D plays an important role in the regulation of the mother-placenta-fetus systemensuring normal growth, weight and development of the fetus, reducing the risks of gestational diabetes mellitus, eclampsia and preterm labor. There is insufficient data in the literature on the vitamin D metabolic pathways in pregnant women, and the available results require confirmation using more accurate methods of determination.Objective: To study of...